MOTS-c for metabolic health

What the evidence says

Evidence tier: Strong animal evidence. Decades of consistent animal evidence; human RCTs are sparse but the mechanism is well-established.

• MOTS-c is a 16-amino-acid peptide your mitochondria release under metabolic stress (Lee et al., 2015).
• Animal models showed improved insulin sensitivity and protection against diet-induced obesity.
• Often called an 'exercise mimetic' (a drug that mimics some effects of exercise) in longevity coverage.

Protocol notes

5-10mg subcutaneous 2-3 times per week for 4-8 weeks. Coordinate with a longevity-focused clinician.

Always with a sports-medicine doctor, telehealth provider, or specialist sign-off. Self-experimenting on injection schedules without clinical input is the most common way people waste money and get hurt.

What to skip

• Vendors without a Certificate of Analysis (COA). Random gym-bro vendors with no third-party testing. The peptide market has a quality-control problem; the answer is COA per peptide, every time.
• Pre-mixed blends from non-pharmacy sources. Compounding pharmacies that produce pre-mixed combinations with COAs are fine. Random vendor "stack vials" are not.
• Massively over-dosed protocols. More is rarely better with peptides. Receptor saturation is real. Stick to evidence-based dosing.

Where to go next

• Full MOTS-c directory entry - status, sourcing, studies, what to skip
• What are peptides - if you skipped the foundation
• How peptides actually work - mechanism in plain English
• The Tier List - which ones to take seriously
• Subscribe to the dispatch

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