Every peptide ranked by evidence base, real-world track record, and the Editor's pick. S-Tier is what I'd point a friend at first. A-Tier is well-supported but more situational. B-Tier and Watch are interesting science with thin human evidence; read about them, don't start with them. New entries every week.
Tier rationale per peptide. Click any name for the full directory entry. Where a hands-on protocol guide exists, you'll see the protocol link too.
Recovery
Animal evidence consistent across decades. The peptide most worth researching for a stubborn soft-tissue injury that hasn't responded to rest + PT.
Protocol guide ->Weight Loss
22.5% average weight loss in SURMOUNT-1. Plus a quiet liver story most coverage misses. The runaway success of the GLP-1 era.
Starter guide ->Weight Loss
Longest track record. SELECT trial showed 20% reduction in major cardiovascular events. The right starting molecule for many adults with heart-disease history.
Starter guide ->Cognitive (intl)
Approved as a prescription drug in 50+ countries. Strongest cognitive-peptide evidence base. Sourcing in the US is the hard part.
Recovery
The cell-migration partner to BPC-157 in the Wolverine blend. Pair with BPC-157 if your sports-med doc agrees and you can source with COA per peptide.
Protocol guide ->Skin & Recovery
Topical evidence is solid (skin firming, wound healing). Injectable evidence is thinner; topical is the right entry point for most.
Sexual Health
Bremelanotide. FDA-approved as Vyleesi for premenopausal HSDD. Real trial data behind it. Side-effect profile (nausea) is the trade-off most users notice.
Body Comp & GH
Long-acting GHRH analog. Half of the most-stacked GH protocol on the internet. Safety case in healthy adults isn't fully established.
Body Comp & GH
Selective GHRP. The cleaner-side-effect-profile half of the CJC-1295 stack. Solo use is mostly not worth it; the combo is the point.
Immune
Approved as Zadaxin in 35+ countries for hepatitis and chemotherapy support. Real international clinical use, decades of safety data.
Longevity
Pineal-gland tetrapeptide from Russian gerontology. Telomere claims are interesting. Western replication is sparse.
Cognitive
Same Khavinson-lab lineage as Epitalon. Cognitive-protocol entry; treat as a watch, not a starter.
Longevity
Mitochondrial-derived "exercise mimetic." Real animal evidence. Human trials sparse. Not a substitute for exercise.
Cognitive
Approved as a prescription anxiolytic in Russia. Western replication thin. Worth knowing about; not first-line for anxiety.
Cognitive
ACTH-derived neuroprotective peptide. Approved in Russia for stroke recovery. Strongest Russian-cognitive-peptide evidence base.
Step-by-step plans for the protocols people actually run. Each guide is doctor-supervised, COA-required, four-week-bounded.
Step-by-Step · 4-Week Plan
A doctor-supervised path for the soft-tissue injury that hasn't healed.
PROTOCOL · 002Stack Protocol · 4-Week Plan
BPC-157 stacked with TB-500. The most-discussed recovery combo on the internet, sourced right.
PROTOCOL · 003Pre-Decision · Starter Guide
What to know before your first telehealth call about Mounjaro, Wegovy, or compounded tirzepatide.