An editorial ranking of 20 peptides we cover. S-Tier marks topics of high reader interest; it does not mean every entry has strong human evidence, FDA approval, or a recommended treatment path. Check each card's evidence and regulatory limits before drawing conclusions.
Tier rationale per peptide. Click any name for the full directory entry and check the cited evidence before making a health decision.
BPC-157 remains S-Tier for editorial interest, while human injury outcomes and clinical safety remain uncertain. See the 2025 systematic review and FDA's July 2026 assessment.
Recovery
Mostly animal research. One small retrospective knee-pain study offers limited human outcome data; clinical safety remains unknown. Not FDA-approved for injury treatment. Read the evidence limits ->
Weight Loss
22.5% average weight loss in SURMOUNT-1. Plus a quiet liver story most coverage misses. The runaway success of the GLP-1 era.
Starter guide ->Weight Loss
Longest track record. SELECT trial showed 20% reduction in major cardiovascular events. The right starting molecule for many adults with heart-disease history.
Starter guide ->Cognitive (intl)
Approved as a prescription drug in 50+ countries. Strongest cognitive-peptide evidence base. Sourcing in the US is the hard part.
Recovery
Often discussed with BPC-157 as the Wolverine blend. Human evidence for the combination is not established; a vendor COA does not establish clinical safety or benefit.
Protocol guide ->Skin & Recovery
Topical evidence is solid (skin firming, wound healing). Injectable evidence is thinner; topical is the right entry point for most.
Sexual Health
Bremelanotide. FDA-approved as Vyleesi for premenopausal HSDD. Real trial data behind it. Side-effect profile (nausea) is the trade-off most users notice.
Body Comp & GH
Long-acting GHRH analog. Half of the most-stacked GH protocol on the internet. Safety case in healthy adults isn't fully established.
Body Comp & GH
Selective GHRP. The cleaner-side-effect-profile half of the CJC-1295 stack. Solo use is mostly not worth it; the combo is the point.
Immune
Approved as Zadaxin in 35+ countries for hepatitis and chemotherapy support. Real international clinical use, decades of safety data.
Weight Loss
FDA-approved as Foundayo in 2026 - the first GLP-1 in pill form. About 12.4% weight loss, below the injectables, but no needles and no cold chain. The adherence play, not the efficacy king.
Longevity
Pineal-gland tetrapeptide from Russian gerontology. Telomere claims are interesting. Western replication is sparse.
Cognitive
Same Khavinson-lab lineage as Epitalon. Cognitive-protocol entry; treat as a watch, not a starter.
Longevity
Mitochondrial-derived "exercise mimetic." Real animal evidence. Human trials sparse. Not a substitute for exercise.
Cognitive
Approved as a prescription anxiolytic in Russia. Western replication thin. Worth knowing about; not first-line for anxiety.
Cognitive
ACTH-derived neuroprotective peptide. Approved in Russia for stroke recovery. Strongest Russian-cognitive-peptide evidence base.
Sleep
1977 sleep peptide. Foundational claim hasn't held up after almost five decades.
Longevity / Mitochondrial
FDA-approved as Forzinity for Barth syndrome, a rare mitochondrial disease. Real, approved, and not proven for the anti-aging use the longevity crowd wants. Read, don't start.
Gut & Inflammation
Anti-inflammatory tripeptide from alpha-MSH. Clean mechanism, encouraging animal data for gut and skin, almost no human trials. The thinnest evidence base we cover.
Background on protocols people discuss, including evidence and safety limits. A clinician can assess individual medical decisions; these guides do not validate unapproved peptide use.
Evidence and safety review
What remains unproven about BPC-157 for soft-tissue injury, including limited human data and unknown clinical safety.
PROTOCOL · 002Combination evidence review
Why discussion of BPC-157 with TB-500 does not establish the combination's safety or benefit.
PROTOCOL · 003Pre-Decision · Starter Guide
What to know before your first telehealth call about Mounjaro, Wegovy, or compounded tirzepatide.
Find a topic, compare the evidence, and check the cited sources at your own pace.