TB-500 · For rotator cuff repair

TB-500 for rotator cuff repair

Shoulder injury, considering TB-500 over or with BPC-157.

A-Tier Recovery Moderate animal evidence

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Why people use TB-500 for rotator cuff repair

Shoulder injury, considering TB-500 over or with BPC-157. The short answer: yes, this is one of the more-discussed uses for TB-500 - but the evidence quality and the right protocol depend on what you're actually trying to fix.

This page covers what's known, what's not, and what the editorial take is for normal humans considering TB-500 for rotator cuff repair.

What the evidence says

Evidence tier: Moderate animal evidence. Reasonable animal evidence; mechanism plausible but human translation is unproven.

Cell-migration mechanism complementary to BPC-157's blood-vessel growth.
Often paired with BPC-157 in 'Wolverine blend' protocols.
Animal evidence for soft-tissue healing across decades of veterinary use.

Protocol notes

2-2.5mg subcutaneous twice weekly for 4-6 weeks. Often stacked with BPC-157.

Always with a sports-medicine doctor, telehealth provider, or specialist sign-off. Self-experimenting on injection schedules without clinical input is the most common way people waste money and get hurt.

How it's dosed (quick version)

Most users run 2 to 2.5 milligrams twice a week (a 'loading' phase) for four to six weeks, then drop to 2mg once a week for maintenance if needed. Inject under the skin (subQ). Always with a doctor, and know that TB-500 is banned by WADA for tested athletes.

Typical starting dose: 2 mg subQ (under-the-skin shot) twice weekly for the first 2 weeks. This is the loading phase - higher early dose to saturate tissue.
Typical maintenance dose: 2 to 2.5 mg twice weekly for 4-6 weeks total. After that, drop to 2 mg once weekly for ongoing maintenance if needed.
Frequency: Twice weekly during loading (Mon/Thu is the common pattern). Once weekly for maintenance.
Cycle length: 4 to 6 weeks of loading followed by 4 to 8 weeks of weekly maintenance is the standard cycle.

Full dosing breakdown ->

What to skip

Vendors without a Certificate of Analysis (COA). Random gym-bro vendors with no third-party testing. The peptide market has a quality-control problem; the answer is COA per peptide, every time.
Pre-mixed blends from non-pharmacy sources. Compounding pharmacies that produce pre-mixed combinations with COAs are fine. Random vendor "stack vials" are not.
Massively over-dosed protocols. More is rarely better with peptides. Receptor saturation is real. Stick to evidence-based dosing.

Where to go next

Full TB-500 directory entry - status, sourcing, studies, what to skip
What are peptides - if you skipped the foundation
How peptides actually work - mechanism in plain English
The Tier List - which ones to take seriously
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Last reviewed · 2026-05-07 · Page generated by Protocol One matrix engine